Call: 08-737 88 00 Efficacy and safety of ABT-494, a selective JAK-1 inhibitor, in a phase IIb study in patients with rheumatoid arthritis and an 08-737 88 00.
6 Oct 2011 ABT-737 is a cell-permeant compound that binds to Bcl-2 and Bcl-xL but not to Mcl-1. Using a myeloma cell line collection (n = 25) representative
ABT 737 also inhibits Bcl-w and Bcl-xl. ABT-737 is a selective and BH3 mimetic Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. - Mechanism of Action & Protocol. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
2007-01-15 · ABT-737. A potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins. Catalog NO: CT-A737: Synonym ABT-737 induced several hallmarks of autophagy. However, knockdown of beclin-1, a key regulator of entry into autophagy, diminished the efficacy of ABT-737, suggesting either that the effects of chloroquine were nonspecific or that induction but not completion of autophagy is necessary for the combined effect of ABT-737 and chloroquine. Buy ABT-737, CAS: 852808-04-9, item number: SYN-1001-M001 from SYNkinase at Biomol! Adding ABT‐737 efficiently induced apoptosis of hepatoma cells, clearly indicating that the target of ABT‐737, presumably Bcl‐xL, blocks the apoptosis‐inducing potency of sorafenib.
The small molecule inhibitor, ABT-737, which binds to and inhibits Bcl-2, Bcl-xL and Bcl-w, was used in combination with doxorubicin/AN-9 treatments to overcome resistance to doxorubicin–DNA adducts in Bcl-2 overexpressing HL-60 cells (HL-60/Bcl-2).
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BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that
BH3 mimetic ABT-737 induces apoptosis. Sample Page Supplementary MaterialsSupplementary Information 41467_2018_7213_MOESM1_ESM. March 10, 2021 by abt737
ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress.
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Ingående ackumulerade AB 04 och ABT 06. Not 33. Förfallotidpunkt från Boije 737.
Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 18437895 · BCL-2 Dependence and ABT-737 Sensitivity in Acute Lymphoblastic Leukemia
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Grunder i LOU. Grunder i AB/ABT/ABK/AMA 20 737 500. 10 368 750 ABT 94 och ABT 06 för totalentreprenader samt ABK 96 och ABK 09.
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might overcome chemoresistance.
2011-10-06 · ABT-737 is a cell-permeant compound that binds to Bcl-2 and Bcl-x(L) but not to Mcl-1. Using a myeloma cell line collection (n = 25) representative of different molecular translocations, we showed that ABT-737 effectively kills a subset of cell lines (n = 6), with a median lethal dose ranging from 7 ± 0.4 nM to 150 ± 7.5 nM.
ABT-737 binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl-2 protein family, including Bcl-2, Bcl-xl and Bcl-w. ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
ABT-737 is a novel and potent inhibitor of B-cell lymphoma 2 (BCL-2) family proteins, which are critical for cell survival and overexpressed in many tumor cells, with high affinity towards BCL-X L, BCL-2, and BCL-w but no affinity towards less homologous proteins, such as BCL-B, MCL-1, and A1. ABT-737 is a BH3 mimetic that acts as an inhibitor of Bcl-2, Bxl-xl, and Bcl-ω.